Motif ID: TFAP2{A,C}.p2

Z-value: 5.892


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Achr6_-_10523424-0.282.9e-01Click!
TFAP2Cchr20_+_54637714-0.126.5e-01Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_-_52877467 7.857 IRX3
iroquois homeobox 3
chr14_-_24588916 7.386 NM_014178
STXBP6
syntaxin binding protein 6 (amisyn)
chr16_+_52877009 7.261


chr17_+_56832255 6.652 TBX2
T-box 2
chr19_+_15079141 6.567 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr11_-_60819110 6.486 VWCE
von Willebrand factor C and EGF domains
chr17_+_56831951 6.424 NM_005994
TBX2
T-box 2
chr2_-_45090025 6.330 NM_016932
SIX2
SIX homeobox 2
chr19_+_39664706 6.281 NM_001080436
WTIP
Wilms tumor 1 interacting protein
chr9_+_115958051 6.161 NM_032888
COL27A1
collagen, type XXVII, alpha 1
chr16_-_52876390 5.913 IRX3
iroquois homeobox 3
chr2_+_36436873 5.580 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr19_+_38377329 5.578 NM_002333
LRP3
low density lipoprotein receptor-related protein 3
chr9_-_83493415 5.324 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr1_+_226937732 5.302 RHOU
ras homolog gene family, member U
chr14_+_92049396 5.262 NM_024832
RIN3
Ras and Rab interactor 3
chr11_-_60819273 5.191 NM_152718
VWCE
von Willebrand factor C and EGF domains
chr5_+_129268352 5.140 NM_175856
CHSY3
chondroitin sulfate synthase 3
chr16_-_49742651 5.076 NM_002968
SALL1
sal-like 1 (Drosophila)
chr5_-_159672060 5.019 NM_024565
CCNJL
cyclin J-like
chr10_-_76829857 4.963 ZNF503
zinc finger protein 503
chr9_+_115957537 4.937 COL27A1
collagen, type XXVII, alpha 1
chr20_+_44771532 4.925 NM_030777
SLC2A10
solute carrier family 2 (facilitated glucose transporter), member 10
chr2_+_236068029 4.920 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr22_-_19122107 4.720 NM_153334
NM_182895
SCARF2

scavenger receptor class F, member 2

chr7_+_94374862 4.715 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr3_+_51403760 4.704 NM_013286
RBM15B
RNA binding motif protein 15B
chr16_-_52877868 4.686 NM_024336
IRX3
iroquois homeobox 3
chr15_-_46724360 4.604 FBN1
fibrillin 1
chr3_+_50217692 4.576 NM_006841
SLC38A3
solute carrier family 38, member 3
chr3_-_130807865 4.562 NM_015103
PLXND1
plexin D1
chr18_-_53621277 4.526 NM_005603
ATP8B1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr10_+_101079099 4.366 CNNM1
cyclin M1
chr5_+_92946348 4.341 NR2F1
nuclear receptor subfamily 2, group F, member 1
chr17_+_52026058 4.289 NM_005450
NOG
noggin
chr2_+_85834111 4.274 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr7_+_288051 4.235 NM_020223
FAM20C
family with sequence similarity 20, member C
chr15_+_64782468 4.091 SMAD6
SMAD family member 6
chr4_+_72271218 4.048 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr12_-_105056577 4.032 NUAK1
NUAK family, SNF1-like kinase, 1
chr21_+_36993860 3.987 NM_005069
NM_009586
SIM2

single-minded homolog 2 (Drosophila)

chr22_-_32646325 3.976 NM_004737
NM_133642
LARGE

like-glycosyltransferase

chr8_-_38444982 3.968 FGFR1
fibroblast growth factor receptor 1
chr10_-_131652364 3.961 EBF3
early B-cell factor 3
chr16_-_52877829 3.937 IRX3
iroquois homeobox 3
chr4_+_108965167 3.922 NM_001136258
SGMS2
sphingomyelin synthase 2
chr2_+_36436316 3.899 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr5_+_72957736 3.883 NM_001080479
NM_001177693
RGNEF

190 kDa guanine nucleotide exchange factor

chr12_-_78608154 3.844 PAWR
PRKC, apoptosis, WT1, regulator
chr19_-_18578467 3.827 CRLF1
cytokine receptor-like factor 1
chr18_+_18969724 3.820 NM_001100619
CABLES1
Cdk5 and Abl enzyme substrate 1
chr1_-_212791467 3.794 PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr2_+_120820140 3.785 NM_002193
INHBB
inhibin, beta B
chr2_+_39746525 3.742 NM_152390
TMEM178
transmembrane protein 178
chr2_+_159533329 3.738 NM_001145909
NM_033394
TANC1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr2_-_236741352 3.681 NM_001485
GBX2
gastrulation brain homeobox 2
chrX_-_54538591 3.674 FGD1
FYVE, RhoGEF and PH domain containing 1
chr7_-_27136876 3.669 NM_002141
HOXA4
homeobox A4
chr4_-_141896920 3.657 NM_015130
TBC1D9
TBC1 domain family, member 9 (with GRAM domain)
chr21_+_36993302 3.639


chr16_-_71639670 3.638 NM_006885
ZFHX3
zinc finger homeobox 3
chr7_+_140420500 3.608 NM_001195278
LOC100131199
transmembrane protein 178-like
chr20_+_34206070 3.605 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr17_+_62391216 3.594 NM_014405
CACNG4
calcium channel, voltage-dependent, gamma subunit 4
chr2_+_235525355 3.569 NM_014521
SH3BP4
SH3-domain binding protein 4
chr14_-_102593384 3.564 NM_006035
CDC42BPB
CDC42 binding protein kinase beta (DMPK-like)
chr17_+_56832492 3.549 TBX2
T-box 2
chr1_-_16355013 3.519 NM_004431
EPHA2
EPH receptor A2
chr14_-_29466562 3.500 NM_002742
PRKD1
protein kinase D1
chr7_-_45927263 3.459 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr9_+_136673464 3.444 NM_000093
COL5A1
collagen, type V, alpha 1
chr1_+_2975590 3.419 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr19_-_15172773 3.382 NM_000435
NOTCH3
notch 3
chr14_+_68796621 3.370 GALNTL1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1
chr6_+_19945578 3.366 NM_001546
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr19_-_18578631 3.363 NM_004750
CRLF1
cytokine receptor-like factor 1
chr9_-_111300350 3.353 NM_001145368
NM_002829
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr2_-_219633481 3.335 NM_002181
IHH
Indian hedgehog
chr6_+_107917965 3.329 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr6_-_128883125 3.300 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr9_-_135847106 3.298 NM_001134398
NM_003371
VAV2

vav 2 guanine nucleotide exchange factor

chr4_+_3434830 3.290 NM_001164673
NM_173660
DOK7

docking protein 7

chr8_+_30361485 3.285 NM_001008710
NM_001008711
NM_001008712
NM_006867
RBPMS



RNA binding protein with multiple splicing



chr8_+_37672427 3.267 NM_025069
ZNF703
zinc finger protein 703
chr3_+_148610516 3.250 ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr3_+_114414064 3.223 NM_033254
BOC
Boc homolog (mouse)
chr2_-_197165495 3.190 NM_020760
HECW2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr14_+_64240902 3.163 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr6_-_132314004 3.156 NM_001901
CTGF
connective tissue growth factor
chr12_+_79995927 3.152 NM_024560
ACSS3
acyl-CoA synthetase short-chain family member 3
chr18_-_24010944 3.150 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr2_-_42573980 3.134 KCNG3
potassium voltage-gated channel, subfamily G, member 3
chr9_-_37566248 3.125 NM_012166
FBXO10
F-box protein 10
chr15_+_78483624 3.114 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr10_+_128583984 3.078 NM_001380
DOCK1
dedicator of cytokinesis 1
chr10_-_118491971 3.066 NM_025015
HSPA12A
heat shock 70kDa protein 12A
chr6_+_53767747 3.056 LRRC1
leucine rich repeat containing 1
chr12_-_94708641 3.045 NM_021229
NTN4
netrin 4
chr20_+_4077466 3.029 SMOX
spermine oxidase
chr10_-_725522 3.027 NM_014974
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr10_+_59942874 3.018 NM_001080512
BICC1
bicaudal C homolog 1 (Drosophila)
chr18_-_24011349 3.017 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr2_-_101370291 3.011 CREG2
cellular repressor of E1A-stimulated genes 2
chr12_-_94708477 3.008 NTN4
netrin 4
chr3_+_112273464 3.005 NM_015480
PVRL3
poliovirus receptor-related 3
chr15_-_66511488 3.001 NM_001004439
ITGA11
integrin, alpha 11
chr7_+_6622051 2.994 NM_017560
ZNF853
zinc finger protein 853
chr20_-_4177519 2.993 NM_000678
ADRA1D
adrenergic, alpha-1D-, receptor
chr20_+_6696744 2.975 NM_001200
BMP2
bone morphogenetic protein 2
chr7_+_288195 2.966 FAM20C
family with sequence similarity 20, member C
chr17_+_35751796 2.952 NM_001024809
RARA
retinoic acid receptor, alpha
chr10_-_131652007 2.949 NM_001005463
EBF3
early B-cell factor 3
chr4_+_185064799 2.933 STOX2
storkhead box 2
chr14_+_64240996 2.929 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr12_-_105165805 2.925 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr3_+_112273352 2.917 PVRL3
poliovirus receptor-related 3
chr2_+_173000590 2.892 ITGA6
integrin, alpha 6
chr15_+_49421004 2.889 NM_181789
GLDN
gliomedin
chr2_-_175255717 2.881 NM_001077269
WIPF1
WAS/WASL interacting protein family, member 1
chr20_+_11819364 2.879 NM_181443
BTBD3
BTB (POZ) domain containing 3
chr2_+_149895274 2.875 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr14_+_69021149 2.855 NM_001161498
UPF0639
UPF0639 protein
chr3_+_185580554 2.829 NM_003741
CHRD
chordin
chr19_-_62043867 2.812 NM_001146326
NM_001146327
NM_015363
NM_001146184
NM_001146185
NM_001146187
NM_006210
ZIM2


PEG3



zinc finger, imprinted 2


paternally expressed 3



chr10_+_123862430 2.808 TACC2
transforming, acidic coiled-coil containing protein 2
chr16_+_88517187 2.804 NM_006086
TUBB3
tubulin, beta 3
chr2_-_224612177 2.788 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr22_-_19122047 2.788 SCARF2
scavenger receptor class F, member 2
chr2_+_42128521 2.785 NM_138370
PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr16_+_639278 2.783 NM_145294
WDR90
WD repeat domain 90
chr18_-_22382497 2.773 NM_001142730
KCTD1
potassium channel tetramerisation domain containing 1
chr20_+_2031418 2.769 STK35
serine/threonine kinase 35
chr15_-_53667800 2.754 PYGO1
pygopus homolog 1 (Drosophila)
chr14_+_68796433 2.746 NM_001168368
NM_020692
GALNTL1

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1

chr15_+_66658626 2.743 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr17_-_64108331 2.739 FAM20A
family with sequence similarity 20, member A
chr7_+_27190688 2.733


chr16_+_85158357 2.728 NM_005251
FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr2_+_109112428 2.728 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr16_-_51138306 2.725 NM_001080430
TOX3
TOX high mobility group box family member 3
chrX_+_46318135 2.717 NM_019886
CHST7
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
chr21_-_27139143 2.677 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr15_+_82113813 2.651 NM_207517
ADAMTSL3
ADAMTS-like 3
chr4_-_158111995 2.643 NM_016205
PDGFC
platelet derived growth factor C
chrX_+_68641802 2.641 NM_015686
FAM155B
family with sequence similarity 155, member B
chr22_+_36531246 2.641 H1F0
H1 histone family, member 0
chr1_+_39319675 2.638 NM_012090
MACF1
microtubule-actin crosslinking factor 1
chr6_+_157141565 2.634 ARID1B
AT rich interactive domain 1B (SWI1-like)
chr2_+_176761552 2.624 NM_024501
HOXD1
homeobox D1
chr5_+_98132898 2.621 NM_001012761
RGMB
RGM domain family, member B
chr3_+_44878380 2.603 NM_144638
TMEM42
transmembrane protein 42
chr6_+_1555679 2.586 NM_001453
FOXC1
forkhead box C1
chr8_-_97242119 2.581 NM_001001557
GDF6
growth differentiation factor 6
chr11_-_65396775 2.578 NM_016938
EFEMP2
EGF containing fibulin-like extracellular matrix protein 2
chr16_+_66244314 2.570 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr17_-_19711580 2.568 NM_001142610
NM_014683
ULK2

unc-51-like kinase 2 (C. elegans)

chr17_-_64108529 2.565 NM_017565
FAM20A
family with sequence similarity 20, member A
chr19_-_54557450 2.562 NM_003598
TEAD2
TEA domain family member 2
chr12_-_15833617 2.560 NM_004447
EPS8
epidermal growth factor receptor pathway substrate 8
chr18_-_22383066 2.555 NM_001136205
KCTD1
potassium channel tetramerisation domain containing 1
chr14_-_93324518 2.551 NM_178013
PRIMA1
proline rich membrane anchor 1
chr12_+_108636569 2.550 NM_032829
C12orf34
chromosome 12 open reading frame 34
chr14_+_32478209 2.547 NM_001164749
NM_001165893
NM_022123
NM_173159
NPAS3



neuronal PAS domain protein 3



chr11_-_1549719 2.536 NM_004420
DUSP8
dual specificity phosphatase 8
chr20_+_8060762 2.528 NM_015192
NM_182734
PLCB1

phospholipase C, beta 1 (phosphoinositide-specific)

chr7_+_3307445 2.522 NM_152744
SDK1
sidekick homolog 1, cell adhesion molecule (chicken)
chr19_+_1200882 2.504 MIDN
midnolin
chr2_+_42129440 2.494


chr6_-_132764257 2.494 NM_015529
MOXD1
monooxygenase, DBH-like 1
chr14_-_76677711 2.493 ZDHHC22
zinc finger, DHHC-type containing 22
chr10_+_104394185 2.493 NM_030912
TRIM8
tripartite motif containing 8
chr20_+_60906605 2.491 NM_007346
OGFR
opioid growth factor receptor
chr11_+_61204392 2.484 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr20_-_49818268 2.477 ATP9A
ATPase, class II, type 9A
chr10_+_20145350 2.476 NM_032812
PLXDC2
plexin domain containing 2
chr10_-_76831142 2.474 ZNF503
zinc finger protein 503
chr2_+_241586927 2.473 NM_001080437
SNED1
sushi, nidogen and EGF-like domains 1
chr8_-_38444675 2.468 FGFR1
fibroblast growth factor receptor 1
chr7_+_128615948 2.461 NM_005631
SMO
smoothened homolog (Drosophila)
chr20_+_34635362 2.460 NM_021809
TGIF2
TGFB-induced factor homeobox 2
chr2_+_171280944 2.460 SP5
Sp5 transcription factor
chr1_-_85703198 2.452 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr2_+_109729176 2.438 NM_023016
ANKRD57
ankyrin repeat domain 57
chr1_-_95165037 2.438 CNN3
calponin 3, acidic
chr12_-_47468985 2.437 NM_020983
ADCY6
adenylate cyclase 6
chr5_-_57791544 2.435 NM_006622
PLK2
polo-like kinase 2
chr1_-_19155360 2.422 NM_001136265
IFFO2
intermediate filament family orphan 2
chr16_-_49742008 2.415 NM_001127892
SALL1
sal-like 1 (Drosophila)
chr7_-_5427367 2.413


chr1_-_112333192 2.412 NM_004980
NM_172198
KCND3

potassium voltage-gated channel, Shal-related subfamily, member 3

chr20_-_30534848 2.407 NM_080616
C20orf112
chromosome 20 open reading frame 112
chr18_+_17076166 2.404 NM_001142966
GREB1L
growth regulation by estrogen in breast cancer-like
chr3_+_189354167 2.399 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr10_+_71482542 2.394 H2AFY2
H2A histone family, member Y2
chr10_+_122206455 2.384 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr8_+_25098296 2.375 DOCK5
dedicator of cytokinesis 5
chr2_+_54536780 2.363 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr7_-_27206249 2.360 NM_000522
HOXA13
homeobox A13
chr14_+_105063975 2.358 NM_025268
TMEM121
transmembrane protein 121
chr20_-_30535045 2.356 C20orf112
chromosome 20 open reading frame 112

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 2.44e-27 GO:0009987 cellular process
1.11 1.99e-18 GO:0050794 regulation of cellular process
1.15 2.95e-18 GO:0044260 cellular macromolecule metabolic process
1.10 2.57e-17 GO:0050789 regulation of biological process
1.10 2.84e-17 GO:0065007 biological regulation
1.11 1.18e-14 GO:0044237 cellular metabolic process
1.16 2.12e-14 GO:0071840 cellular component organization or biogenesis
1.16 3.16e-14 GO:0016043 cellular component organization
1.13 3.34e-14 GO:0043170 macromolecule metabolic process
1.18 2.17e-13 GO:0071841 cellular component organization or biogenesis at cellular level
1.18 4.18e-13 GO:0071842 cellular component organization at cellular level
1.25 4.22e-13 GO:0007399 nervous system development
1.09 1.14e-12 GO:0008152 metabolic process
1.10 3.60e-12 GO:0044238 primary metabolic process
1.19 1.69e-10 GO:0048523 negative regulation of cellular process
1.30 1.76e-10 GO:0048699 generation of neurons
1.29 2.51e-10 GO:0022008 neurogenesis
1.17 3.85e-10 GO:0048519 negative regulation of biological process
1.15 7.72e-10 GO:0048856 anatomical structure development
1.17 1.77e-09 GO:0048522 positive regulation of cellular process
1.13 2.24e-09 GO:0032502 developmental process
1.28 2.75e-09 GO:0048468 cell development
1.20 5.16e-09 GO:0006996 organelle organization
1.21 1.85e-08 GO:0009653 anatomical structure morphogenesis
1.12 4.56e-08 GO:0031323 regulation of cellular metabolic process
1.14 5.86e-08 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.30 5.91e-08 GO:0030182 neuron differentiation
1.14 6.62e-08 GO:0048731 system development
1.12 1.10e-07 GO:0007275 multicellular organismal development
1.14 1.31e-07 GO:0048518 positive regulation of biological process
1.19 1.92e-07 GO:0023051 regulation of signaling
1.32 5.21e-07 GO:0048666 neuron development
1.20 5.64e-07 GO:0009966 regulation of signal transduction
1.30 8.40e-07 GO:0030030 cell projection organization
1.25 9.99e-07 GO:0050793 regulation of developmental process
1.11 1.22e-06 GO:0019222 regulation of metabolic process
1.17 2.07e-06 GO:0006464 protein modification process
1.11 2.09e-06 GO:0080090 regulation of primary metabolic process
1.27 2.38e-06 GO:2000026 regulation of multicellular organismal development
1.15 2.42e-06 GO:0048869 cellular developmental process
1.33 2.78e-06 GO:0031175 neuron projection development
1.14 3.20e-06 GO:0044267 cellular protein metabolic process
1.15 3.45e-06 GO:0090304 nucleic acid metabolic process
1.16 3.87e-06 GO:0030154 cell differentiation
1.28 4.22e-06 GO:0045595 regulation of cell differentiation
1.25 5.29e-06 GO:0051128 regulation of cellular component organization
1.16 5.50e-06 GO:0043412 macromolecule modification
1.28 1.19e-05 GO:0032989 cellular component morphogenesis
1.12 1.47e-05 GO:0034641 cellular nitrogen compound metabolic process
1.11 1.65e-05 GO:0060255 regulation of macromolecule metabolic process
1.28 1.99e-05 GO:0051726 regulation of cell cycle
1.28 2.00e-05 GO:0000902 cell morphogenesis
1.11 2.18e-05 GO:0006807 nitrogen compound metabolic process
1.31 2.22e-05 GO:0000904 cell morphogenesis involved in differentiation
1.10 3.27e-05 GO:0023052 signaling
1.21 6.09e-05 GO:0007049 cell cycle
1.30 6.84e-05 GO:0048858 cell projection morphogenesis
1.30 6.90e-05 GO:0032990 cell part morphogenesis
1.18 7.59e-05 GO:0035556 intracellular signal transduction
1.22 7.86e-05 GO:0010605 negative regulation of macromolecule metabolic process
1.11 8.31e-05 GO:0007165 signal transduction
1.43 9.38e-05 GO:0002009 morphogenesis of an epithelium
1.19 1.04e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.09 1.17e-04 GO:0051716 cellular response to stimulus
1.31 1.35e-04 GO:0048812 neuron projection morphogenesis
1.26 1.38e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
1.22 1.40e-04 GO:0006351 transcription, DNA-dependent
1.21 1.48e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.18 1.49e-04 GO:0009893 positive regulation of metabolic process
1.32 1.65e-04 GO:0007409 axonogenesis
1.20 1.69e-04 GO:0032268 regulation of cellular protein metabolic process
1.31 1.75e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.23 2.52e-04 GO:0031399 regulation of protein modification process
1.18 2.88e-04 GO:0031325 positive regulation of cellular metabolic process
1.20 4.47e-04 GO:0009892 negative regulation of metabolic process
1.15 5.13e-04 GO:0016070 RNA metabolic process
1.25 6.03e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.21 6.13e-04 GO:0031324 negative regulation of cellular metabolic process
1.23 7.43e-04 GO:0009890 negative regulation of biosynthetic process
1.23 9.18e-04 GO:0009790 embryo development
1.11 9.77e-04 GO:0019538 protein metabolic process
1.14 1.10e-03 GO:0048583 regulation of response to stimulus
1.42 1.15e-03 GO:0045664 regulation of neuron differentiation
1.36 1.33e-03 GO:0035295 tube development
1.09 1.40e-03 GO:0051179 localization
1.14 1.46e-03 GO:0010467 gene expression
1.16 1.76e-03 GO:0051239 regulation of multicellular organismal process
1.32 2.03e-03 GO:0007411 axon guidance
1.88 2.13e-03 GO:0035050 embryonic heart tube development
1.34 2.23e-03 GO:0048729 tissue morphogenesis
1.23 2.30e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.30 2.50e-03 GO:0007264 small GTPase mediated signal transduction
1.33 2.52e-03 GO:0060284 regulation of cell development
1.23 2.60e-03 GO:0007167 enzyme linked receptor protein signaling pathway
1.18 2.77e-03 GO:0051246 regulation of protein metabolic process
1.15 2.96e-03 GO:0065009 regulation of molecular function
1.42 3.64e-03 GO:0035239 tube morphogenesis
1.24 3.90e-03 GO:0010629 negative regulation of gene expression
1.30 4.18e-03 GO:0051056 regulation of small GTPase mediated signal transduction
1.16 4.19e-03 GO:0051641 cellular localization
1.32 4.77e-03 GO:0033043 regulation of organelle organization
1.46 4.91e-03 GO:0060562 epithelial tube morphogenesis
1.54 5.01e-03 GO:0061138 morphogenesis of a branching epithelium
1.18 5.02e-03 GO:0032774 RNA biosynthetic process
1.17 5.14e-03 GO:0044248 cellular catabolic process
1.23 6.39e-03 GO:0000278 mitotic cell cycle
1.18 7.66e-03 GO:0006793 phosphorus metabolic process
1.18 7.66e-03 GO:0006796 phosphate metabolic process
1.17 8.72e-03 GO:0010646 regulation of cell communication
1.24 9.58e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.13 9.78e-03 GO:0034645 cellular macromolecule biosynthetic process
1.15 9.80e-03 GO:0033036 macromolecule localization
1.13 1.09e-02 GO:0009059 macromolecule biosynthetic process
1.25 1.12e-02 GO:0072358 cardiovascular system development
1.25 1.12e-02 GO:0072359 circulatory system development
1.29 1.22e-02 GO:0048598 embryonic morphogenesis
1.11 1.24e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.22 1.42e-02 GO:0009887 organ morphogenesis
1.23 1.43e-02 GO:0051253 negative regulation of RNA metabolic process
1.17 1.50e-02 GO:0008104 protein localization
1.22 1.56e-02 GO:0051276 chromosome organization
1.35 1.58e-02 GO:0051129 negative regulation of cellular component organization
1.19 1.66e-02 GO:0022402 cell cycle process
1.34 1.78e-02 GO:0050767 regulation of neurogenesis
1.10 1.80e-02 GO:0010556 regulation of macromolecule biosynthetic process
1.16 1.81e-02 GO:0051649 establishment of localization in cell
1.34 1.85e-02 GO:0030036 actin cytoskeleton organization
1.10 1.88e-02 GO:0051171 regulation of nitrogen compound metabolic process
1.22 1.97e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.24 2.10e-02 GO:0007010 cytoskeleton organization
1.22 2.50e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.10 2.56e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.29 2.60e-02 GO:0045597 positive regulation of cell differentiation
1.32 2.95e-02 GO:0051960 regulation of nervous system development
1.31 3.10e-02 GO:0030029 actin filament-based process
1.26 3.24e-02 GO:0016477 cell migration
1.23 3.58e-02 GO:0044265 cellular macromolecule catabolic process
1.16 4.05e-02 GO:0043067 regulation of programmed cell death
1.16 4.18e-02 GO:0010941 regulation of cell death
1.23 4.83e-02 GO:0007417 central nervous system development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.09 7.05e-35 GO:0044424 intracellular part
1.08 1.39e-33 GO:0005622 intracellular
1.09 2.79e-25 GO:0043226 organelle
1.09 7.81e-25 GO:0043229 intracellular organelle
1.10 1.01e-24 GO:0043227 membrane-bounded organelle
1.10 1.37e-24 GO:0005737 cytoplasm
1.10 3.94e-24 GO:0043231 intracellular membrane-bounded organelle
1.13 4.36e-18 GO:0005634 nucleus
1.21 3.90e-16 GO:0044428 nuclear part
1.21 8.00e-13 GO:0031981 nuclear lumen
1.10 1.86e-12 GO:0044422 organelle part
1.10 3.12e-12 GO:0044446 intracellular organelle part
1.10 5.01e-12 GO:0044444 cytoplasmic part
1.18 1.49e-11 GO:0031974 membrane-enclosed lumen
1.18 3.62e-11 GO:0070013 intracellular organelle lumen
1.17 9.99e-11 GO:0043233 organelle lumen
1.17 3.46e-09 GO:0005829 cytosol
1.19 8.31e-07 GO:0005654 nucleoplasm
1.46 3.52e-05 GO:0031252 cell leading edge
1.11 6.08e-05 GO:0043228 non-membrane-bounded organelle
1.11 6.08e-05 GO:0043232 intracellular non-membrane-bounded organelle
1.09 1.09e-04 GO:0032991 macromolecular complex
1.10 1.22e-04 GO:0043234 protein complex
1.02 1.91e-04 GO:0005623 cell
1.02 2.19e-04 GO:0044464 cell part
1.20 2.33e-03 GO:0044451 nucleoplasm part
1.13 3.23e-03 GO:0012505 endomembrane system
1.22 1.18e-02 GO:0005730 nucleolus
1.29 3.71e-02 GO:0005635 nuclear envelope

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 5.65e-29 GO:0005515 protein binding
1.07 9.48e-23 GO:0005488 binding
1.16 2.09e-08 GO:0000166 nucleotide binding
1.28 4.05e-08 GO:0019899 enzyme binding
1.17 7.87e-08 GO:0017076 purine nucleotide binding
1.17 1.31e-07 GO:0035639 purine ribonucleoside triphosphate binding
1.17 1.66e-07 GO:0032553 ribonucleotide binding
1.17 1.66e-07 GO:0032555 purine ribonucleotide binding
1.23 1.98e-07 GO:0030528 transcription regulator activity
1.23 5.13e-07 GO:0001071 nucleic acid binding transcription factor activity
1.23 5.13e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.17 1.63e-06 GO:0030554 adenyl nucleotide binding
1.17 3.40e-06 GO:0032559 adenyl ribonucleotide binding
1.17 5.69e-06 GO:0005524 ATP binding
1.21 3.24e-05 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.24 5.11e-05 GO:0043565 sequence-specific DNA binding
1.30 6.93e-05 GO:0004674 protein serine/threonine kinase activity
1.28 1.24e-04 GO:0030695 GTPase regulator activity
1.23 1.26e-04 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.21 2.17e-04 GO:0016301 kinase activity
1.27 5.64e-04 GO:0060589 nucleoside-triphosphatase regulator activity
1.23 1.18e-03 GO:0004672 protein kinase activity
1.30 2.47e-03 GO:0016563 transcription activator activity
1.26 3.24e-03 GO:0019904 protein domain specific binding
1.23 5.60e-03 GO:0008092 cytoskeletal protein binding
1.06 1.27e-02 GO:0003824 catalytic activity
1.34 2.59e-02 GO:0000975 regulatory region DNA binding
1.34 2.59e-02 GO:0001067 regulatory region nucleic acid binding
1.34 2.59e-02 GO:0044212 transcription regulatory region DNA binding
1.28 2.69e-02 GO:0005083 small GTPase regulator activity
1.10 3.61e-02 GO:0003677 DNA binding
1.33 4.51e-02 GO:0010843 promoter binding